Pig’s ’ere – and far from a bore

First love

When I was a lad I quite often worked on my Uncle’s farm in Cumberland and it was there that I first fell in love. It was reciprocated too, in a sort of way – I think largely contingent on presenting myself regularly bearing armfuls of potato peelings and summoning the courage to lean over the wall and do a bit of ear tickling. To this day pigs remain a love of my life and, given my enthusiasm for the wonders of DNA sequencing, readers will be unsurprised that the convergence of the two is irresistible.

Sequencing Sus scrofa

The genome sequence of a female domestic pig (with the less than alluring name of T. J. Tabasco), together with those of some of her relatives, have just been published. Before we get on to why you less love-struck unfortunates should give a grunt, we should make clear that no animals were harmed in unveiling this sequence. Rather, a small piece of an ear or a few teaspoons of blood were enough to grow cells from which DNA was distributed to the research groups involved.

1.11807_Pig1_cutout

Almost like a pig

So what did the members of the Swine Genome Sequencing Consortium gives us as the result of their labours? Well some things you would have guessed anyway: pigs have about as much DNA in their cells as we do (about 3,000 million base pairs). Of course they do: they’d have to be pretty similar for folk to go round falling in love with them. And within that sequence they have more genes encoding smell receptors than any other animal (over 1300) – which obviously helps if you have to rootle around for a bite to eat and not become reliant on admirers bringing gifts, though you can sense a downside to being so olfactorily endowed.

Them and us

But what about the differences? Well, close though I feel to them, pigs and humans last had a common ancestor about 90 million years ago and a domesticated pig first trotted out of South East Asia about 4 million years ago. Separate strains of the domestic pig then evolved in western Europe and East Asia that diverged from the various strains of wild boar – though the separation is somewhat murky due to pigs being prone to roam – a habit that led to what is delicately called ‘genetic mixing.’ So Hampshires and Large Whites turn out to be more closely related to European wild boars than they are to Chinese pigs such as the Meishan.

Model humans

One of the things that happened as pigs went their separate evolutionary way is that their DNA became unusually prone to being broken. Although damaged DNA is usually repaired two consequences tend to arise. Sometimes a gene just gets lost and this has happened with quite a few that we originally shared with pigs that enable us to taste things like salt: by losing that sensitivity pigs have acquired the ability to eat things we can’t. The other result is that pigs are quite good at shuffling bits of DNA to make novel genes (and hence proteins) – something called alternative splicing. But perhaps the most important outcome is that pig DNA has acquired about 100 changes (mutations) that in humans are linked to increased risk of things like Alzheimer’s disease and diabetes.

Pigs have a long and noble history as good models for human disease and we use their heart valves in replacement surgery (how’s that for reciprocated love?). Having a peek at their DNA has revealed that they also offer a natural model to find out what happens in some of our worst afflictions.

Pigs: giving us their hearts, sorting out our frailties – and making more roast dinners than you can shake a stick at. Everyone should love ‘em!

Reference

Groenen, M.A.M. et al., (2012). Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491, 393-398.

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