Not another ‘Great Cancer Breakthrough’!!!

Since I started writing Betrayed by Nature and this accompanying blog, my take on science reporting in the ‘media’ has undergone considerable change. I guess most of it used to wash over me: now I feel obliged to read it, with a view to making sense of it from the point of view of non-scientists. The dramatic headlines generally fall into two groups – one telling us what not to do/eat, the other revealing how wonderful scientists are.

I admitted recently (Whose side are you on?) that as far as the eating, drinking and exercising injunctions go, I’m beginning to side with those who just wish ‘they’d’ keep quite and let us get on doing whatever we want to do. The other group is trickier because there’s almost always some interesting stuff beneath the press rhetoric. The latest Scientists hail revolutionary breast cancer breakthrough is a case in point. The media coverage refers to a paper just published in Nature that has applied the formidable power of nucleic acid sequencing methods to a large number of breast tumours. The sheer amount of information generated is almost stupefying and the efforts of folk – called ‘bioinformaticists’ – who make sense of the raw data are remarkable.

But the overall message is relatively simple. Like every other tumour, each breast cancer is different at the level of the molecular changes it carries. However, the DNA sequences of genes and the extent to which they are ‘switched on’ to make RNA and protein (‘gene expression’) permit these tumours to be sub-divided into 10 major categories.

So is this a ‘Great Cancer Breakthrough’. Not really. It’s a terrific piece of science but it’s just one more small step towards better designed therapies that’s come from using the wonderful methods that have become available over the last ten years or so.

Did the guys who did the work use the hyped-up language of Mr. Connor in The Independent? Not exactly. This paper is a stunning technical tour-de-force – but the authors merely sign off with the comment that their work ‘reveals novel subgroups that should be the target of future investigation’.


Curtis, C., Shah, S.P., Chin, S.-F., Turashvili, G., Rueda, O.M. et al. (2012). The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature (2012) doi:10.1038/nature10983