Dennis’s Pet Menace

As it happened, I’d already agreed to appear on Jeremy Sallis’ Lunchtime Live Show on BBC Radio Cambridgeshire – the plan being just to chat about cancery topics that might be of interest to listeners. Which would have been fine – if only The World Health Organization had left us in peace. But of course they chose last Tuesday to publish their lengthy cogitations on the subject of whether meat is bad for us – i.e. causes cancer.

Cue Press extremism: prime example The Times, quite predictably – they really aren’t great on biomedical science – who chucked kerosene on the barbie with the headline ‘Processed meats blamed for thousands of cancer deaths a year’.

But – to precise facts – and strictly it’s The International Agency for Research on Cancer, the cancer agency of the World Health Organization (WHO), that has ‘evaluated the carcinogenicity of the consumption of red meat and processed meat.’

But hang on … haven’t we been here before?

Indeed we have. As long ago as January 2012 in these pages we commented on the evidence that processed meat can cause pancreatic cancer and in May of the same year we reviewed the cogitations of the Harvard School of Public Health’s 28 year study of 120,000 people that concluded eating red meat contributes to cardiovascular disease, cancer and diabetes. To be fair, that history partially reflects why the WHO Working Group of 22 experts from 10 countries have taken so long to go public: they reviewed no fewer than 800 epidemiological studies! However, as the most frequent target for study was colorectal (bowel) cancer, that was the focus of their report released on 26th October 2015.

So what are we talking about?

Red meat, which means any unprocessed mammalian muscle meat, e.g., beef, veal, pork, lamb, mutton, horse or goat meat, that we usually cook before eating.

Processed meat: any meat not eaten fresh that has been salted, cured, smoked or whatever and commonly treated with chemicals to enhance flavour and colour and to prevent the growth of bacteria.

What did they say?

Processed meat is now classified as carcinogenic to humans – that is it goes into the top group (Group 1) of agents that cause cancer.

Red meat is probably carcinogenic to humans (Group 2A). Group 2B is for things that are possibly carcinogenic to humans.

Why?

Because 12 of the 18 studies they reviewed showed a link between consumption of processed meat and bowel cancer and because it’s known that agents commonly added to processed meat (nitrates and nitrites) can, when we eat them, turn into chemicals that can directly damage DNA, i.e. cause mutations and hence promote cancers.

For red meat 7 out of 15 studies showed positive associations of high versus low consumption with bowel cancer and there is strong mechanistic evidence for a carcinogenic effect i.e. when meat is cooked genotoxic (i.e. DNA-damaging) chemicals can be generated. They put red meat in the probably group because several of the studies that the Working Group couldn’t fault – and therefore couldn’t leave out – showed no association.

Stop woffling

My laptop likes to turn ‘woffling’ into ‘wolfing’. Maybe it’s trying to tell me something.

But is The WHO trying to tell us something specific about wolfing? To be fair, they have a go by estimating that every 50 gram portion of processed meat (say a couple of slices of bacon) eaten daily increases the risk of bowel cancer by about 18%. For red meat the data ‘suggest’ that the risk of bowel cancer could increase by 17% for every 100 gram portion eaten daily.

And what might that mean?

In the UK about 6 people in 100 get bowel cancer: if you take The WHO maximum estimate and have everyone eat 50 grams of processed meat every day of their lives such that 18% more of them would get bowel cancer, the upshot would be 7 people in 100 rather than 6. So it’s a small rise in a relatively small risk.

As the report points out, the Global Burden of Disease Project reckons diets high in processed meat cause about 34,000 cancer deaths per year worldwide and, if the reported associations hold up, the figure for red meat would be 50,000. Compare those figures with smoking that increases the risk of lung cancer by 20-fold and The WHO’s estimate of up to 6 million cancer deaths per year globally caused by tobacco use and 600,000 per year by alcohol consumption.

All of which suggests that it isn’t very helpful to lump meat eating, tobacco and asbestos in the same cancer-causing category and that The WHO could do worse than come up with a new classification system.

And the message?

Unchanged. Remember mankind evolved into the most successful species on the planet as a meat eater. As the advert used to say: It looks good, it tastes good and by golly it does you good – not least as a source of protein, vitamins and other nutrients. Do some exercise and eat a balanced diet – just in case you’ve forgotten, that means limit the amount of red meat (The WHO suggests no more than 30 grams a day for men, 25 g for women) so try fish, poultry, etc. Stick with the ‘good carbs’ (vegetables, fruits, whole grains, etc.), cut out the ‘bad’ (sugar – see Biting the Bitter Bullet), eat fishy fats not saturated fats and, to end on a technical note, don’t pig out.

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‘The Divine Swine’ Castelnuovo Rangone, Italy

Meanwhile back on the Beeb

When the meat story broke I was a bit concerned that we might end up spending the whole of Lunchtime Live on how many bangers are lethal – especially as we were taking calls from listeners. Just in case things became a bit myopic I had Rasher up my sleeve. Rasher, you may recall, was Dennis the Menace‘s pet pig (in the The Beano‘s comic strip) who had a brother (Hamlet), a sister (Virginia Ham) and various other porky rellos. To bring it up to date we’d have introduced Sam Salami and Frank Furter and, of course, Rasher’s grandfather who was the model for the bronze statue named ‘The Divine Swine’ to be found in the little town of Castelnuovo Rangone in Pig Valley, Italy, the home of Parma ham.

But I shouldn’t have worried. All was well in the hands of Jeremy Sallis who, being a brilliant host, ensured that we mainly chatted about meatier matters than what to have for breakfast.

References

Press release: IARC Monographs evaluate consumption of red meat and processed meat.

Q&A on the carcinogenicity of the consumption of red meat and processed meat.

Carcinogenicity of consumption of red and processed meat. www.thelancet.com/oncology Published online October 26, 2015

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Rasher Than I Thought?

A recent report concluding that if you eat processed meat (bacon, sausages and suchlike) you’re more likely to get cancer in your pancreas has attracted predictably wide media coverage. More surprisingly, the reports I noticed (BBC News, Sky News and Guardian) were fairly reasonable accounts, quoting the main figures, the source of the information (British Journal of Cancer) and one or two ‘expert’ comments thereon. Usually science reporting in the ‘media’ is more feel than fact and appears to be motivated by coming up with eye-catching headlines rather than precise explanations (being precise, there is a Bacon Eaters Warned Of Deadly Cancer Risk in the above – but let’s not be too critical).

What the papers didn’t say

What such reports almost always fail to mention – and these were no exception – is how devilishly difficult it is to do surveys linking what we eat to what happens to our bodies. One method is to get a group of people with a given disease and ask them what they’ve eaten over the last umpty months/years/decades. You don’t need to be a stats wizard to see the major problem with this! Alternatively, so-called ‘prospective studies’ start with healthy individuals who are followed for exposure to potential factors and subsequent development of disease. Exposed and unexposed sub-groups are compared for disease rates. There are huge problems with these studies too, not the least being that you have no real idea how well the punters stick to the rules – in this case, what they eat.

The predictable upshot over many years has been that, apart from fruit and veg (good anti-cancer stuff, as we all know), for pretty well every survey showing something we eat gives us cancer there’s another that says it either has no effect or it’s actually protective.

Much easier than actually doing either type of survey is to do what these processed meaters did: put together all the sensible studies you can find (in this case eleven prospective surveys between 1966 and 2011) and see if a clear message emerges. Though not perhaps evident at first sight, this is actually quite a useful thing to do because by lumping all the data together you get a large number of patients and controls and the hope is that, out of the confusion of multiple smaller surveys, clarity will come forth.

And, up to a point, it did. The relative risk of pancreatic cancer emerged as 1.19 if you eat 50 g of processed meat every day (it would be 1.00 if you take The World Cancer Research Fund’s advice and avoid the stuff altogether). And, of course, the risk goes up the more of it you eat.

How scary is that?

So where does that leave us and how scared should we be by the scary headline? Have I been unwittingly irresponsible indulging a life-long taste for bacon, sausages and such like? Mmm…bacon…Mmm…sausages. (Sorry – Homeric moment there). Well, something like a 20% risk increase may be significant but it isn’t huge. Then 50 g is a fair wodge of bacon or whatever to eat every day. What’s more, the authors admitted that they’d had to make a few assumptions about just how much processed meat people actually had eaten in the various studies they collated, because some only listed ‘servings’ or ‘times’. Then there’s the question of how is the deed done if processed meat does drive cancer? The study authors noted that the most likely culprit is preservatives commonly added to such food – because these can indirectly cause DNA mutations. Having just salivated round the wondrous display of meats, hams, bacons, sausages etc. in my local Farm Shop (Gog Magog Hills: don’t miss it if you’re anywhere near Cambridge) I note than none of their stuff contains additives or preservatives. Whew!!

And the bottom line…

So my advice to me is: don’t panic, don’t pig out – but do keep an eye on where piggy bits come from. All of which is not to minimise the threat of pancreatic cancer. It’s the eighth biggest cancer killer worldwide, nearly 8,000 Brits died from it in 2008 and there’s no effective treatment. What’s the best thing to do – or not to do? Well, as we’ve said, take it easy on the bacon butties. But two things are strongly associated with pancreatic cancer: smoking (contributes to 20% of cases) and obesity. Not smoking’s easy, of course. Now, how to avoid getting fat…

Reference

Larsson, S.C. and Wolk, A. (2012). Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies. British Journal of Cancer advance online publication 12 January 2012; doi: 10.1038/bjc.2011.585.